Symbol
Name
ID

Klf1
Kruppel-like transcription factor 1 (erythroid)
MGI:1342771

Phenotype annotations related to hematopoietic system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Reduced hematocrit

Persistence of hemoglobin F

Decreased hemoglobin concentration

Erythroid hyperplasia

Reticulocytosis

Anemia

Hemolytic anemia

Anemia of inadequate production

Anisocytosis

Circulating nucleated red blood cells

Increased RBC distribution width

Poikilocytosis

Schistocytosis

Splenomegaly

Hepatosplenomegaly

Disease(s) Associated with KLF1

congenital dyserythropoietic anemia type IV

Mouse Phenotypes

hematopoietic system phenotype

enlarged spleen

increased spleen weight

abnormal erythropoiesis

anemia

impaired hematopoiesis

erythroblastosis

abnormal erythrocyte morphology

decreased erythrocyte cell number

decreased hematocrit

decreased hemoglobin content

decreased mean corpuscular hemoglobin

increased nucleated erythrocyte cell number

anisocytosis

poikilocytosis

polychromatophilia

abnormal embryonic erythrocyte morphology

increased spleen iron level

increased erythrocyte osmotic fragility

Availability

Mouse Genotype

Klf1^Nan/Klf1^Nan

Klf1^tm1.1Ryan/Klf1^tm1.1Ryan

Klf1^tm1Nimr/Klf1^tm1Nimr

Klf1^tm1Sho/Klf1^tm1Sho

Klf1^Nan/Klf1⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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